Cytokines and the CNS, Second Edition by Richard M. Ransohoff (Editor), Etty N. Benveniste (Editor)

By Richard M. Ransohoff (Editor), Etty N. Benveniste (Editor)

Presents perception into How Cytokine motion affects the body structure and Pathology of the CNS. As with the 1st version of Cytokines and the CNS, this thoroughly up-to-date and revised version introduces neurobiologists to cytokine biology and immunologists to the original capabilities of cytokines in CNS body structure. The dramatically accelerating curiosity in cytokines and cytokine/chemokine signaling over the last a number of years has inspired an explosion of literature on cytokines. The similarity among elements thinking about irritation or immunity, and people implicated in neural improvement, body structure, and service has turn into so obvious that familiarity with cytokines needs to now be thought of a necessary point within the neurobiologist’s cognitive tool-kit. Conversely, for immunobiologists, the options elaborated through neurobiologists to appreciate developmental patterning and networked organ functionality proceed to conform in one of these manner that comprehension of cytokine motion within the CNS can merely increase yet another knowing of immune approach function.  Cytokines and the CNS, moment variation is patterned after the 1st version; although, the wealth of information now to be had provides a major volume of perception and new implications. to assure a clean point of view, the editors made a wide awake option to make the most of a wholly new set of participants, all specialists in numerous elements of cytokine learn. Cytokines and the CNS, moment variation begins with a bankruptcy at the CNS, concentrating on pathological reactions to insult. subsequent, come 3 chapters on cytokine biology, by way of 4 chapters that combine cytokine biology into simple CNS strategies (development; irritation; immunity; degeneration/repair), and then 5 chapters observe this physique of data to affliction or pathology. The publication closes with a glance on the program of cytokine biology to the therapy of illness, a new quarter of research. 

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62. Basu A. et al. The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury, J. Neurosci. 22, 6071, 2002. 63. S. et al. Glial-neuronal interactions in Alzheimer’s disease: the potential role of a ‘cytokine cycle’ in disease progression, Brain Pathol. 8, 65, 1998. 64. E. Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer’s disease, J Leukoc.

Oppenheim, J. J. , Introduction to the role of cytokines in innate host defense and adaptive immunity, In Cytokine Reference 1, Oppenheim, J. J. , Academic Press, 2001, pp. 3–20. 10. , Thomson, A. W. and Lotze, M. , Academic Press, 2003, pp. 3–18. 11. Bennett, I. , Jr. and Beeson, P. , Studies on the pathogenesis of fever, II: characterization of fever-producing substances from polymorphonuclear leukocytes and from the fluid of sterile exudates, J. Exp. Med. 98, 493–508, 1953. 12. Levi-Montalcini, R.

Fm Page 23 Wednesday, September 7, 2005 5:18 PM 2 Cytokines: Wherefrom and Whereto Jan Vilcek ´ CONTENTS I. What Are Cytokines? 23 II. Evolution of the Cytokine Field ..................................................................... 25 III. Brief Survey of Major Cytokine Families...................................................... 28 IV. Unique Features of Cytokine Actions ............................................................ 32 V. Conclusion.......................................................................................................

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