By Harald H. H. W. Schmidt, Franz B. Hofmann, Johannes-Peter Stasch
After the invention of endogenous NO formation within the overdue '80s and the 1998 Nobel Prize in body structure or medication, many researchers and physicians back got interested within the NO/sGC interplay and cGMP-dependent signaling. This publication is an enthusiastic social gathering of cyclic guanosine monophosphate (cGMP) and amply illustrates the significance of this box of technological know-how to sufferers and how during which the sector has advanced. it truly is completely dedicated to this fascinating and demanding signaling molecule, addressing all contemporary advances in figuring out guanylate cyclase rules, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. specific cognizance can also be given to medical purposes of the unconventional cGMP-elevating medicinal drugs that are at the horizon, therefore spanning the continuum from easy technology to sanatorium.
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Extra resources for cGMP: Generators, Effectors and Therapeutic Implications
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 34 36 44 Abstract The NO/cGMP signalling cascade has an important role in smooth muscle relaxation, inhibition of platelet aggregation and neuronal transmission. Although the function of the main NO receptor GC (NO-GC) is well established, the particular tasks of the NO receptor isoforms (NO-GC1 and NO-GC2) are unclear and NO targets other than NO-GC have been postulated.
Dissertation, The University of Michigan Winger JA, Marletta MA (2005) Expression and characterization of the catalytic domains of soluble guanylate cyclase: interaction with the heme domain. Biochemistry 44:4083–4090 Winger JA, Derbyshire ER, Marletta MA (2006) Dissociation of nitric oxide from soluble guanylate cyclase and H-NOX domain constructs. J Biol Chem 282:897–907 Yuen PS, Potter LR, Garbers DL (1990) A new form of guanylyl cyclase is preferentially expressed in rat kidney. Biochemistry 29:10872–10878 Zhang GY, Liu Y, Ruoho AE, Hurley JH (1997) Structure of the adenylyl cyclase catalytic core.
W. Schmidt et al. ), cGMP: Generators, Effectors and Therapeutic Implications, Handbook of Experimental Pharmacology 191, c Springer-Verlag Berlin Heidelberg 2009 33 34 E. Mergia et al. particulate and cytosolic cell fractions (Chrisman et al. 1975). e. nitric oxide for the soluble enzyme (Palmer et al. 1987) and atrial natriuretic peptide for the membrane forms (Kuno et al. 1986). The membrane-bound GCs and their respective activators are discussed in more detail in another chapter of this book.