By Kjell Öberg, Gunnar Alm (auth.), Huub Schellekens (eds.)
This publication, written via prime authors within the box, is the 1st to house all facets of cytokine antibodies, from try out method and standardization to organic results and capabilities. It encompasses antibodies brought on by means of cytokines used therapeutically and antiviral antibodies. to appreciate the biology, the consequences of cytokine antibodies in experimental animal types and sufferers also are mentioned. The ebook is meant for researchers of cytokine biology, pharmaceutical businesses constructing cytokines and cytokine antibodies as cures, and clinicians attracted to modulating the immune approach as therapy.
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Additional info for Antibodies in Cytokines: The concerted action on the antigenicity of rDNA derived pharmaceuticals
1). Affinity purification. Human IFN-, antibodies were purified from human Ig preparations taken from healthy subjects by a one-step chromatographic procedure using a recombinant IPN-,-coupled Sepharose CL4B affinity column . The antibodies to lPN-, were eluted from the column by 3 different methods with no loss of immunological activity. These were found to be immunoglobulins of the IgO 1 subclass. 0. In this case, the application of the first buffer allowed a partial elution of lPN-, antibodies, which became complete only when the second buffer, characterized by a relatively high pH and by high ionic strength, was applied.
The recent findings that type I IFNs are potent inducers of IL-IO production by peripheral blood mononuclear cells (PBMCs) may provide at least one explanation for this phenomenon (47, 48). Among the various biological activities, IL-I 0 has been shown to enhance proliferation and Ig production by B cells most likely by preventing apoptosis of the germinal centre (GC) B cells (49-51). This apoptotic mechanism is considered crucial for the demise of autoreactive B cells in the B cell forming areas of the secondary lymphoid organs (52).
Hatched bar: medium only. to interfere in vitro with the antiviral, antiproliferative and immunomodulating activity of IPN-,. Human anti-lPN-, antibodies did not impair the antiviral and antiproliferative activity of IPN-,. However, they interfered with the immunomodulating activity ofthe Iymphokine . U937 cells incubated in a medium containing lPN-" increased the expression of HLA-DR antigens on their surface. The maximum effect was reached at 24 h, with lPN-'/' at a concentration of 200 U/ml.