Anti-Idiotypes, Receptors, and Molecular Mimicry by D. Scott Linthicum, Nadir R. Farid

By D. Scott Linthicum, Nadir R. Farid

Here is an updated evaluate of significant new tools and ends up in anti-idiotypes, receptors, and molecular mimicry.It starts with a dialogue of the theoretical history ofthe anti-idiotypic community, it truly is function within the legislation of immune reaction, and the actual features of anti-idiotypic antibodies. It then is going directly to discover many exciting purposes in such parts as insulin motion, thyroid mobile functionality, the neurosciences, cardiology, virology, pharmacology, and copy.

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Hoppe-Seyler's Z. Physiol. Chern. 352:859. 17. F. Deutsch. 1982. Primary structure ofa human A-chain (Weir) of the Mcg type. Mol. Immunol. 19:90 I. 18. T. Wu, and H. Bilofsky. 1977. Unusual distributions of amino acids in complementarity-determining (hypervariable) segments of heavy and light chains of immunoglobulins and their possible roles in specificity of antibody-combining sites. J. BioI. Chern. 252:6609. 4. Anti-Idiotypes as Probes of Immunoglobulin Structure 33 19. J. , C. N. Davidson. 1973.

Panagiotopoulos. 1975. Rotational allomerism and divergent evolution of domains in immunoglobulin light chains. Biochemistry 14:3953. 16. , and N. Hilschmann. 1971. Die vollstandige Primar-struktur einer monoklonalen immunoglobulin-I-Kette von I-Typ, Subgruppe II (Bence-Jones Protein ViI). Hoppe-Seyler's Z. Physiol. Chern. 352:859. 17. F. Deutsch. 1982. Primary structure ofa human A-chain (Weir) of the Mcg type. Mol. Immunol. 19:90 I. 18. T. Wu, and H. Bilofsky. 1977. Unusual distributions of amino acids in complementarity-determining (hypervariable) segments of heavy and light chains of immunoglobulins and their possible roles in specificity of antibody-combining sites.

Rice. 1982. Identification of aM, 58000 glycoprotein subunit of the opiate receptor. FEBS Lett. 150: 125. 13. D. D. L. E. Blalock. 1986. Antibodies to the binding site of the LHRH receptor: generation with a synthetic decapeptide encoded by a RNA complementary to LHRH mRNA. Proc. Natl. Acad. Sci. USA, 83:9714. 14. J. Catt. 1985. Photoaffinity labeling of pituitary and gonadal receptors for gonadotropin-releasing hormone. Endocrinology 117:738. 15. L. E. Blalock. 1987. Generation of idiotypic and anti-idiotypic antibodies by immunization with peptides encoded by complementary RN As: A possible molecular basis for the network theory.

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