Advances in veterinary science and comparative medicine. by James L Bittle; Frederick A Murphy

By James L Bittle; Frederick A Murphy

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Extra info for Advances in veterinary science and comparative medicine. Vol. 33, Vaccine biotechnology

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Salmonella is a facultative intracellular pathogen; therefore, cell-mediated immunity is more important than humoral immunity in resistance to the disease, salmonellosis (Fields et ah, 1986a,b; Dougan et ah, 1987; Woolcock, 1973). Salmonella typhi, the only Salmonella species that has a capsular polysaccharide (Vi antigen), is the etiologic agent of typhoid fever, a serious and common disease in underdeveloped areas (Edelman and Levine, 1986). This pathogen infects humans only; there is no suitable animal model for typhoid fever.

1982). , 1981). Immunization. , 1982). Prior infection with one serotype provides protection from heterologous serotypes (Nielsen, 1976). The bacterial strains used in vaccines are serotype specific and, while not preventing the disease, can reduce its severity (Christensen, 1982). 2. Hemophilus somnus Hemophilus somnus is the cause of infectious meningoencephalitis, a disease with low morbidity but high mortality in cattle. , 1978). The bacterins of H. somnus, adjuvanted with aluminum hydroxide, are prepared from highly immunogenic strains of the bacterium and grown in serum-free media for use as vaccines.

C. 4. C. 5. C. B. Bacillus E. C. Erysipelothrix Erysipelothr D. F. Clostridium 1. C. 2. C. perfringens novyi chauvoei septicum Mycobacterium Streptococcus 1. S. agalactiae 2. S. pneumoniae tetani A. Corynebacterium The genus Corynebacterium is a heterogeneous grouping with its species placed together largely on the basis of similar cell wall components (Goodfellow and Minnikin, 1981). These species share a basic cell wall chemistry (Barksdale, 1981) of which the mycolic acids (Silva and Ioneda, 1977), especially trehalose dimycolate, are frequently used as potent adjuvants in immunization protocols.

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